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Indian Academy Degree College – Autonomous, Department of Biochemistry, organized a guest lecture on: “Barrier lifted in understanding function in disease and drug mechanisms”, for UG and PG Life Science students, on 19th February, 2019.

Barrier lifted in understanding function in disease and drug mechanisms 2019

The guest speaker was Dr. Anurag P. Srivastava who is currently working as an Assistant Professor, Garden City University, Bangalore. This talk is sponsored by DBT Star College Program.

The speaker started his talk by sharing his postdoctoral research experiences at Rosalind Franklin University of Medicine and Science, USA under the supervision of Prof. David M. Mueller on the topic “Structural and functional studies of yeast ATP synthase” that was published in a highly prestigious Journal ‘Science’ as the first author (http://science.sciencemag.org/content/360/6389/eaas9699). He started his lecture from the discovery of antibiotics and antibiotic resistance in pathogens such as Mycobacterium tuberculosis. He also highlighted the various factors responsible for emergence of antibiotic resistance in microorganisms. He, then discussed about his work in his post doc lab, where they wanted to develop drugs against ATP Synthase of Mycobacterium. To develop drugs targeting mycobacterial ATP Synthase, they first sought to understand the structure and function of ATP Synthase with the inhibitor drug, Oligomycin by cryoelectron microscopy. However, oligomycin binds to both eukaryotic and bacterial ATP synthase, albeit at different parts of the ATP synthase complex. Therefore he concluded his talk by discussing that oligomycin could be modified so that it selectively binds to the bacterial ATP Synthase and not the eukaryotic ATP synthase. The talk was well received by both the students and faculty with an active question & answer session.

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